Developmental (or Cellular) Biology
Researchers in these fields study the normal processes of development and cell function providing important insights into how tumor cells differ from normal cells and how tumors behave. These studies are identifying new targets for breast cancer therapies, exploring the biological basis for potential interactions with environmental exposure and breast cancer development, and also providing insights into why tumors become resistant to treatment.
- Bogi Anderson, MD
Dr. Anderson studies how the body regulates normal breast growth and development. These studies provide critical information on how tumor cells circumvent normal regulation of their growth and development. His studies are providing insights into the function of cancer stem cells.
- James Brody, MD
Dr. Brody integrates epidemiologic data with mathematical models to understand how cancer develops and becomes resistance to treatment. He also studies the molecular biology and biochemical analysis of a module of genes expressed in breast cancers.
- Bruce Blumberg, PhD
Dr. Blumberg studies a receptor that responds to various drugs, dietary or xenobiotic components, and hormones. This receptor is over-expressed in many breast cancers suggesting that it may provide a link between breast cancer and the environment.
- Dr. Philip Carpenter, MD
Dr. Carpenter is the process of how breast cancer cells metastasize, move from one place and start growing in another part of the body. Understanding the metastatic process is important because it is metastatic breast cancer is the source of nearly all breast cancer mortality.
- Frances Jurnak, PhD
Dr. Jurnak uses computer modeling and cellular biology to investigate a molecule that is highly expressed in breast tumors that do not have enough oxygen, called carbonic anhydrase IX. This molecule appears to impart resistance to various therapies including radiation therapy.
- Eva Lee, PhD
Dr. Lee studies how alterations in various genes impact the development of breast cancer using sophisticated genetic models. These models are used to study processes regulating cancer development and molecular basis of differential responses to steroid hormones and chemotherapy in vivo.
- Wen-Hwa Lee, PhD
Dr. Lee is using advanced high throughput screening techniques to evaluate new compounds that target specific genetic changes seen in breast cancer, potentially revealing new "targeted therapies" that could be less toxic than existing treatments.
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